High Neutrophils to Lymphocytes Ratio in Maternal Blood Serum as Risk Factor for Preterm Premature Rupture of Membrane
DOI:
https://doi.org/10.46799/ijssr.v3i9.518Keywords:
inflammation, neutrophil-to-lymphocyte ratio, preterm premature rupture of membranesAbstract
Introduction: Neutrophil-to-lymphocyte ratio (NLR) has been extensively studied as a prognostic factor for various diseases based on systemic inflammation. Premature rupture of membranes (PROM) is an obstetric problem that does not only occur in term pregnancies but can also occur in preterm pregnancies. One of the main etiologies for premature rupture of membranes is inflammation. Knowing the difference in the NLR between preterm prematurerupture of membranes (PPROM) and without PPROM is important to increase understanding of the crucial role of NLR in predicting the incidence of PPROM.
Method: This analytic case-control study compared NLR values ??in maternal blood serum between PPROM and without PPROM. This research was conducted in the emergencydelivery room and obstetrics and gynecology outpatient clinic at Prof. dr. I.G.N.G. Ngoerah Hospital Denpasar from February to June 2022.
Results: A high NLR in maternal blood serum may be a risk factor for PPROM. Patients with a high NLR had a 4.5 times greater likelihood of experiencing PPROM than those with a low NLR (OR = 4.5; 95% CI = 1.4 – 13.83; p = 0.007).
Conclusion: A high NLR in maternal blood serum is a marker of inflammation with an increased risk of 4.5 times for the occurrence of PPROM.
References
Akboga, M., Canpolat, U., Yuksel, M., Yayla, C., Yilmaz, S., Turak, O., Ozeke, O., Topaloglu, S. dan Aras, D., 2015. Platelet to lymphocyte ratio as a novel indicator of inflammation is correlated with the severity of metabolic syndrome: A single center large-scale study. Platelets, 27(2), pp.178-183.
Akkar, BO., Sancakdar, E., Karakus, S., Yildiz, C., Akkar, I., Arslan, M., Sahin, I., Imir Yenicesu, A. dan Cetin, A., 2016. Evaluation of Maternal Serum 25-Hydroxyvitamin D, Paraoxonase 1 Levels, and Neutrophil-to-Lymphocyte Ratio in Spontaneous Preterm Birth. Medical Science Monitor, 22, pp.1238-1243.
Balciuniene, G., Kvederaite-Budre, G., Gulbiniene, V., Dumalakiene, I., Viliene, R., Pilypiene, I., Drasutiene, G.S., Ramasauskaite, D., 2021. Neutrophil-lymphocyte ratio for the prediction of histological chorioamnionitis in cases of preterm premature rupture of membranes: a case-control study. BMC Pregnancy Childbirth 21, 656. https://doi.org/10.1186/s12884-021-04101-z
Bastek, J. A., Sammel, M. D., Srinivas, S. K., McShea, M. A., Foreman, M. N., Elovitz, M. A. and Metlay, J. P. 2012. Clinical prediction rules for preterm birth in patients presenting with preterm labor’, Obstetrics and Gyn
Budijaya, Negara, S. 2016. Profil Persalinan Dengan Ketuban Pecah Dini di RSUP Sanglah Denpasar Periode 1 Januari - 31 Desember 2015. Laporan Penelitian Deskriptif.
Daglar, H. K., Kirbas, A., Kaya, B., & Kilincoglu, F. 2016. The value of complete blood count parameters in predicting preterm delivery. European revfiew for medical and pharmacological sciences, 20(5), pp.801–805.
Gezer C, Ekin A, Solmaz U, Sahingoz Yildirim AG, Dogan A, Ozeren M. Identification of preterm birth in women with threatened preterm labour between 34 and 37 weeks of gestation. J Obstet Gynaecol. 2018; 38(5): 652–7.
Hackenhaar, A. A., Albernaz, E. P., & da Fonseca, T. M. 2014. Preterm premature rupture of the fetal membranes: association with sociodemographic factors and maternal genitourinary infections. Jornal de pediatria, 90(2), pp.197 – 202. https://doi.org/10.1016/j.jped.2013.08.003
Kim MA, Lee BS, Park YW, Seo K. Serum markers for prediction of spontaneous preterm delivery in preterm labour. Eur J Clin Invest. 2011; 41(7): 773–80.
Lakshmi, M.P.A. Sai, and V. Lakshmi Sravani. "Role of neutrophil-lymphocyte ratio in determining the outcomes of preterm premature rupture of membranes." International Journal of Reproduction, Contraception, Obstetrics and Gynecology, vol. 10, no. 4, Apr. 2021, pp. 1617+. Gale OneFile: Health and Medicine, link.gale.com/apps/doc/A659742215/HRCA?u=anon~e4e68633&sid=googleScholar&xid=8d97b8a2. Accessed 26 Dec. 2022.
Maulana, E. and Maulani, U.N., 2021. Perbedaan Karakteristik dan Faktor Lainnya Terhadap Ketuban Pecah Dini (Kpd) di Puskesmas Ciambar Kabupaten Sukabumi Tahun 2018. Jurnal Kesehatan Dan Kebidanan (Journal Of Health And Midwifery), 10(1), pp.1-14.
Melissa, CL., HG, A., HBS, J., GR, A. dan A, J., 2018. Neutrophil to Lymphocyte Ratio and Red Blood Cell Distribution Width Levels in Preterm vs. Term Births. Journal of Molecular and Genetic Medicine, 12(1), pp.1-3.
Movahedi, M., Rezaie, M., Taefnia, A.M. 2013. Maternal and fetal outcomes of preterm premature rupture of membrane. Journal of Isfahan Medical School, 30(216), pp. 2134–2139. doi: 10.5847/wjem.j.1920.
Mubark, A. M. 2015. Neutrophil to lymphocyte ratio & cervical length for prediction of spontaneous preterm delivery in threatened preterm labour.
Ozel, A., Alici Davutoglu, E., Yurtkal, A. and Madazli, R., 2019. How do platelet-to- lymphocyte ratio and neutrophil-to-lymphocyte ratio change in women with preterm premature rupture of membranes, and threaten preterm labour?. Journal of Obstetrics and Gynaecology, 40(2), pp.195-199.
Pradana, T., & Surya, I. 2020. Karakteristik Ibu Bersalin dengan Ketuban Pecah Dini (Aterm & Preterm) di Rumah Sakit Umum Pusat Sanglah Denpasar Periode Juli 2015 – Juni 2016. E-Jurnal Medika Udayana, 9(7), pp.92-97. doi:10.24843/10.24843.MU.2020.V09.i7.P18
Roth E, Pircher H. 2004. IFN-gamma promotes Fas ligand- and perforinmediated liver cell destruction by cytotoxic CD8 T cells. Journal of Immunology. 172:1588–1594
Toprak, E., Bozkurt, M., Dinçgez Çakmak, B., Özçimen, E., Silahl?, M., Ender Yumru, A. and Çal??kan, E., 2017. Platelet to Lymphocyte Ratio: A New Inflammatory Marker for Diagnosis of Preterm Premature Rupture of Membranes. J Turk Ger Gynecol Assoc, 18(3), pp.122-126. DOI:10.4274/jtgga.2017.0028.
Wesche DE, Lomas-Neira JL, Perl M, Chung CS, Ayala A. 2005. Leukocyte apoptosis and its significance in sepsis and shock. Journal of Leukocyte Biology 78:325–337
Zahorec R. 2001. Ratio of neutrophil to lymphocyte counts-rapid and simple parameter of systemic inflammation and stress in critically ill. Bratislavske Lekarske Listy 102:5–14.
Zhan, F., Zhu, S., Liu, H., Wang, Q., dan Zhao, G. (2018). A blood routine test is a good indicator for predicting premature rupture of membranes. J Clin Lab Anal, pp1-7
Published
Issue
Section
License
Copyright (c) 2023 Nicholas Renata Lazarosony, I Wayan Artana Putra, Ryan Saktika Mulyana, I Made Darmayasa, Ida Bagus Gde Fajar Manuaba, I Gde Sastra Winata, I Nyoman Gede Budiana
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-ShareAlike 4.0 International. that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
