Attribution- ShareAlike 4.0 International (CC BY-SA 4.0)
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IJSSR$234,%2881
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This%work%is%licensed%under%a%Attribution-ShareAlike%4.0%International%(CC%BY-SA%4.0)
Negative(Effects(Of(Protamine(On(Myocardium(In(
Paediatrics(Patients(Undergoing(Cardiac(Surgery(Using(A(
Cardiopulmonary(Bypass(Machine%
%
Suprayitno$W
1
,$Dhama$Shinta$S
2
,$William$M
3
,$Muhammad$Eros$Z$S
4
,$Ameru$U
5
,$Atya$Sabrina$M
6'
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6%
Keywords$
$
ABSTRACT$
Negative(Effects,(Protamine,(
Myocardium,(Paediatrics(Patients,(
Cardiac(Surgery,(Cardiopulmonary(
Bypass(Machine.!
(
The( administration( of( protamine,( a( heparin( reversal( agent,( is( an(
integral(part(of(cardiovascular(bypass(protocols,(particularly(in(the(
post-bypass(phase.(In(paediatric(cases,( protamine(is(adm inistered(in(
a( titration( dose.( The( use( of( protamine( is( associated( with( various(
adverse( events,( including( myocardial( impairment.( Proper( dosage(
adjustment(is(crucial(during(protamine(administration,(as(excessive(
doses( may( result( in( the( depression( of( myocardial( function.(
Experimental( studies( examining( protamine( usage( have( revealed(
myocyte( impairments,( such( as( reduced( myocyte( contractility,(
dysfunction( in( signaling( pathways,( and( alterations( in( cardiac(
receptors.(Despite(these(findings,(resea rch(on(the(impact(of(pediatric(
protamine( on( the( myocardium( remains( limited( and( necessitates(
further(investigatio n.(
!
!
6
!
INTRODUCTION))
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CONCLUSION$
$ 2/"83-=>,%7?34,%=?%3??"6=38,<%R=8F%?,+,/3#%3<+,/?,%,::,68?$%PF,%D/"83-=>,%7?34,%=>%6F=#</,>%F3?%>"%
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/,+,/?,<%7?=>4%>"/,D=>,DF/=>,$%T"R,+,/(%8F,%?87<9%8F38%,XD#3=>,<%8F,%,::,68?%":%D/"83-=>,%3<-=>=?8/38=">%
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REFERENCES))
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C37><,/?$!
N=>I3(% B$(% @/.=>3(% B$% ;$(% ;3>#F="8(% K$(% \#?3=,<(% P$(% m% N/3<9(% P$% ;$% M0&0'Q$% \??"6=38=">% ":% KF=#<F""<% N#""<%
2/,??7/,% R=8F% b,:8% \8/=3#% C=J,% 3><% 57>68=">1% C87<9% ":% T=4F% N#""<% 2/,??7/,% =>% 2,<=38/=6?n\<7#8%
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KF3>,9(%;$%\$(%V".,/8?(%]$%a$(%H/".#,R?I=(%U$(%CF3F7#(%C$(%[37<,8(%V$(%m%],,+3>3><3-(%!$%M0&*^Q$%2/"83-=>,%
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3%/=?I%D/,<=68=">%>"-"4/3-%:"/%?,/="7?%3//F98F-=3?%=>%3678,%<=4"X=>%8"X=6=89%3-">4%D,<=38/=6?1%\%
-7#8=6,>8,/%?87<9$%Toxicon(%233$%F88D?1YY<"=$"/4Y*&$*&*^YZ$8"X=6">$0&0'$*&e0h*%
B#F3<<3<(%\$%;$(%f"7??,:(%;$%5$(%B.3<(%\$%\$(%\.<,#?3#3-(%;$%C$(%m%U3-,#(%;$%;$%M0&00Q$%B::,68%":%!,>8=#38=">%
C8/38,49%a7/=>4%K3/<="D7#-">3/9%N9D3??%">%\/8,/=3#%lX94,>38=">%3><%2"?8"D,/38=+,%27#-">3/9%
K"-D#=638=">?% \:8,/% 2,<=38/=6% K3/<=36% C7/4,/91% \% V3><"-=J,<% K">8/"##,<% C87<9$% Journal" of"
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53<3#=(%;$%\$(%23D36"?83?(%K$%\$(%a7I,(%]$%]$(%b,<.,88,/(%;$(%m%l?.3II,>(%;$%M*de^Q$%K3/<="+3?67#3/%<,D/,??3>8%
,::,68%":%D/"83-=>,%?7#DF38,1%,XD,/=-,>83#%?87<9%3><% 6#=>=63#%=-D#=638=">?$%Thorax(%31M'Q(%'0&n'0'$%
F88D?1YY<"=$"/4Y*&$**'^Y8FX$'*$'$'0&%
[/7,>R3#<(%K$%B$(%;3>#F="8(%K$(%KF3>(%\$%U$(%K/3R:"/<Lb,3>(%b$(%5"/,-3>(%K$(%T"#8.9(%T$%;$(%!3>%\/?<,##(%[$%C$(%
V=6F3/<?(%V$(%;"/=3/89(%T$(%m%;6K/=><#,(%N$%H$%M0&*&Q$%V3><"-=J,<(%6">8/"##,<%8/=3#%":%=><=+=<73#=J,<%
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F88D?1YY<"=$"/4Y*&$*&*^YZ$Z366$0&*&$&^$&h^%
International$Journal$of$Social$Service$and$Research%% F88D?1YY=Z??/$/=<R3>=>?8=878,$6"$=<Y%
IJSSR$234,%2886%
T3-,<% \#L53/?=(% 5$% \$(% C3=<% \#L\#93>=(% l$% N$(% ]"?,(% C$(% m% \#LC33<=(% P$%M0&00Q$%2/,<=68=>4% 238=,>8?% 38% V=?I% :"/%
2/"#">4,<%T"?D=83#%C839?%5"##"R=>4%2,<=38/=6?%P/37-38=6%T,3<%A>Z7/=,?%=>%T=4FLA>6"-,%a,+,#"D=>4%
K"7>8/91% \% V,8/"?D,68=+,% K"F"/8% C87<9$% World" Neurosurgery(% 166(% ,'c0n,'ce$%
F88D?1YY<"=$"/4Y*&$*&*^Y]$H)B@$0&00$&e$&&h%
T,></9(% 2$% ]$(% P3=6F-3>(% [$% K$(% m% U,">(% H$%]$%M*dceQ$% PF,% ;9"63/<=3#% K">8/368=#,%V,?D">?,?% 8"%2/"83-=>,%
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hdeGM*&Q^0&^dL'%
T=/<(% V$% N$(% CD=>3#,(% 5$% [$(% T,R,88(% U$% H$(% ;7IF,/Z,,(% V$(% m% K/3R:"/<(% 5$% \$% M*ddhQ$% PF,% <=/,68% ,::,68?% ":%
D/"83-=>,%?7#:38,%">%-9"698,%6">8/368=#,%D/"6,??,?$%Journal"of"Thoracic"and"Cardiovascular"Surgery(%
108M^Q(%**&&n***h$%F88D?1YY<"=$"/4Y*&$*&*^YC&&00LG00'MdhQe&*G'Ld%
T7(%V$(%f3>3?,(%5$(%;6K3##(%2$(%B+3>?(%V$(%V3-3>(%]$(%m%N,##"-"(%V$%M0&00Q$%PF,%B::,68?%":%P3/4,8,<%KF3>4,?%=>%
C9?8,-=6% N#""<% 5#"R% 3><% ;,3>% \/8,/=3#% 2/,??7/,% ">% @/=>,% lX=-,8/9% a7/=>4% K3/<="D7#-">3/9%
N9D3??$% Journal" of" Cardiothoracic" and" Vascular" Anesthesia(% 36MdQ(% 'GG*n'G^&$%
F88D?1YY<"=$"/4Y*&$*&G'Y]$]!K\$0&00$&G$&0'%
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D38=,>8?1%3%W73#=89% =-D/"+,-,>8% ?8"/9$%The"American" Journal" of" the"Medical"Sciences(%365(%C'^0n
C'^'$%F88D?1YY<"=$"/4Y*&$*&*^YC&&&0Ld^0dM0'Q&&^^cLe%
U/3#,+(%\$(%U3#=?>=I(%]$%;$(%N37,/(%\$(%C=/6F(%]$(%5=88I37(%;$(%m%5=?6F#,=>(%P$%M0&0'Q$%A-D368%":%D/"DF9#368=6%=>8/3L
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International$Journal$of$Asian$Education$(%
C7D/39=8>"%H
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First$publication$rights:$
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